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1

Ion Channels in Innate and Adaptive Immunity

Feske, Stefan, Wulff, Heike, Skolnik, Edward Y.

Journal:

Annual Review of Immunology

Year:

2015

Language:

english

File:

PDF, 2.07 MB

english, 2015

2

Development of tetramethylenedisulfotetramine (TETS) hapten library: synthesis, electrophysiological studies and immune response in rabbits

Barnych, Bogdan, Vasylieva, Natalia, Joseph, Tom, Hulsizer, Susan, Nguyen, Hai, Cajka, Tomas, Pessah, Isaac, Wulff, Heike, Gee, Shirley, Hammock, Bruce

Journal:

Chemistry - A European Journal

Year:

2017

Language:

english

File:

PDF, 1.53 MB

english, 2017

3

4-Phenoxybutoxy-substituted heterocycles – A structure–activity relationship study of blockers of the lymphocyte potassium channel Kv1.3

Silke B. Bodendiek, Cédrick Mahieux, Wolfram Hänsel, Heike Wulff

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 611 KB

english, 2009

4

Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants

K. George Chandy, Michael Cahalan, Michael Pennington, Raymond S. Norton, Heike Wulff, George A. Gutman

Journal:

Year:

2001

Language:

english

File:

PDF, 389 KB

english, 2001

5

Recent developments in ion channel pharmacology

Wulff, Heike, Christophersen, Palle

Journal:

Year:

2015

Language:

english

File:

PDF, 334 KB

english, 2015

6

Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice

Lai, Leng K., Valdearcos, Martin, Morioka, Kazuhito, Saxena, Sarah, Feng, Xiaomei, Li, Rong, Uchida, Yosuke, Lijun, An, Li, Wei, Pan, Jonathan, Koliwad, Suneil, Marcucio, Ralph, Wulff, Heike, Maze, Me

Journal:

British Journal of Anaesthesia

Year:

2020

File:

PDF, 1.69 MB

2020

7

ChemInform Abstract: Alkoxypsoralens, Novel Nonpeptide Blockers of Shaker-Type K+ Channels: Synthesis and Photoreactivity.

Heike Wulff, Heiko Rauer, Tim Duering, Christine Hanselmann, Katharina Ruff, Anja Wrisch, Stephan Grissmer, Wolfram Haensel

Journal:

Year:

1999

File:

PDF, 30 KB

1999

8

Structure, Insertion Electrochemistry, and Magnetic Properties of a New Type of Substitutional Solid Solutions of Copper, Nickel, and Iron Hexacyanoferrates/Hexacyanocobaltates.

Antje Widmann, Heike Kahlert, Irena Petrovic-Prelevic, Harm Wulff, J. V. Yakhmi, Nitin Bagkar, Fritz Scholz

Journal:

Year:

2003

Language:

english

File:

PDF, 62 KB

english, 2003

9

The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression

Jenny Lam, Heike Wulff

Journal:

Drug Development Research

Year:

2011

Language:

english

File:

PDF, 213 KB

english, 2011

10

AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers

Yuki Moritoki, Zhe-Xiong Lian, Heike Wulff, Guo-Xiang Yang, Ya-Hui Chuang, Ruth Y. Lan, Yoshiyuki Ueno, Aftab A. Ansari, Ross L. Coppel, Ian R. Mackay, M. Eric Gershwin

Journal:

Year:

2007

Language:

english

File:

PDF, 670 KB

english, 2007

11

K+ channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for experimental autoimmune encephalomyelitis

Ulf Strauss, Kirsten Wissel, Stefan Jung, Heike Wulff, Wolfram Hänsel, Jie Zhu, Arndt Rolfs, Eilhard Mix

Journal:

Immunopharmacology

Year:

2000

Language:

english

File:

PDF, 324 KB

english, 2000

12

On the chemistry of binding sites VII. Enantioselective binding using chiral boronic acids

Günter Wulff, Heike Stellbrink

Journal:

Recueil des Travaux Chimiques des Pays-Bas

Year:

1990

Language:

english

File:

PDF, 494 KB

english, 1990

13

Electrochemical and mechanochemical formation of solid solutions of potassium copper(II)/zinc(II) hexacyanocobaltate(III)/hexacyanoferrate(III) KCuxZn1-x[hcc]x[hcf]1-x

Antje Widmann, Heike Kahlert, Harm Wulff, Fritz Scholz

Journal:

Journal of Solid State Electrochemistry

Year:

2005

Language:

english

File:

PDF, 489 KB

english, 2005

14

The K+ channels KCa3.1 and Kv1.3 as novel targets for asthma therapy

Peter Bradding, Heike Wulff

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 528 KB

english, 2009

15

Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs

Mads Damkjaer, Gorm Nielsen, Silke Bodendiek, Mette Staehr, Jan-Bert Gramsbergen, Cor de Wit, Boye L Jensen, Ulf Simonsen, Peter Bie, Heike Wulff, Ralf Köhler

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 2.58 MB

english, 2012

16

Voltage-gated potassium channels as therapeutic targets

Wulff, Heike, Castle, Neil A., Pardo, Luis A.

Journal:

Nature Reviews Drug Discovery

Year:

2009

Language:

english

File:

PDF, 644 KB

english, 2009

17

Targeting Effector Memory T Cells with the Small Molecule Kv1.3 Blocker PAP-1 Suppresses Allergic Contact Dermatitis

Azam, Philippe, Sankaranarayanan, Ananthakrishnan, Homerick, Daniel, Griffey, Stephen, Wulff, Heike

Journal:

The Journal of Investigative Dermatology

Year:

2007

Language:

english

File:

PDF, 321 KB

english, 2007

18

Molecular Properties and Physiological Roles of Ion Channels in the Immune System

Michael D. Cahalan, Heike Wulff, K. George Chandy

Journal:

Journal of Clinical Immunology

Year:

2001

Language:

english

File:

PDF, 196 KB

english, 2001

19

Khellinone Derivatives as Blockers of the Voltage-Gated Potassium Channel Kv1.3: Synthesis and Immunosuppressive Activity

Baell, Jonathan B., Gable, Robert W., Harvey, Andrew J., Toovey, Nathan, Herzog, Tanja, Hänsel, Wolfram, Wulff, Heike

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 286 KB

english, 2004

20

Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): The first member of a new κ-KTX subfamily

Thomas Vandendriessche, Ivan Kopljar, David Paul Jenkins, Elia Diego-Garcia, Yousra Abdel-Mottaleb, Elke Vermassen, Elke Clynen, Liliane Schoofs, Heike Wulff, Dirk Snyders, Jan Tytgat

Journal:

Biochemical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.36 MB

english, 2012

21

TRAM-34, a Blocker of the Calcium-activated Potassium Channel KCa3.1, Prevents Acute Transplant Rejection

Heike Wulff, Yi-Je Chen, Girija Raman, Clare Gregory

Journal:

Clinical Immunology

Year:

2007

Language:

english

File:

PDF, 42 KB

english, 2007

22

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

Victor Chi, Michael W. Pennington, Raymond S. Norton, Eric J. Tarcha, Luz M. Londono, Brian Sims-Fahey, Sanjeev K. Upadhyay, Jonathan T. Lakey, Shawn Iadonato, Heike Wulff, Christine Beeton, K. George

Journal:

Year:

2012

Language:

english

File:

PDF, 2.10 MB

english, 2012

23

The ‘functional’ dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels

MOUHAT, Stéphanie, MOSBAH, Amor, VISAN, Violeta, WULFF, Heike, DELEPIERRE, Muriel, DARBON, Hervé, GRISSMER, Stephan, DE WAARD, Michel, SABATIER, Jean-Marc

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 534 KB

english, 2004

24

K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom

MOUHAT, Stéphanie, VISAN, Violeta, ANANTHAKRISHNAN, S., WULFF, Heike, ANDREOTTI, Nicolas, GRISSMER, Stephan, DARBON, Hervé, DE WAARD, Michel, SABATIER, Jean-Marc

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 934 KB

english, 2005

25

Pap-1, a Small Molecule Kv1.3 Blocker, for the Treatment of Effector Memory T-Cell Mediated Autoimmune Diseases

Philippe Azam, Ananthakrishnan Sankaranarayanan, Daniel Homerick, Heike Wulff

Journal:

Clinical Immunology

Year:

2006

Language:

english

File:

PDF, 48 KB

english, 2006

26

K+ channels as targets for specific immunomodulation

K. George Chandy, Heike Wulff, Christine Beeton, Michael Pennington, George A. Gutman, Michael D. Cahalan

Journal:

Trends in Pharmacological Sciences

Year:

2004

Language:

english

File:

PDF, 449 KB

english, 2004

27

Structure–activity relationship exploration of Kv1.3 blockers based on diphenoxylate

Nguyen, William, Howard, Brittany L., Jenkins, David P., Wulff, Heike, Thompson, Philip E., Manallack, David T.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 423 KB

english, 2012

28

The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke

Chen, Yi-Je, Raman, Girija, Bodendiek, Silke, O'Donnell, Martha E, Wulff, Heike

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2011

Language:

english

File:

PDF, 682 KB

english, 2011

29

Structure, Insertion Electrochemistry, and Magnetic Properties of a New Type of Substitutional Solid Solutions of Copper, Nickel, and Iron Hexacyanoferrates/Hexacyanocobaltates

Widmann, Antje, Kahlert, Heike, Petrovic-Prelevic, Irena, Wulff, Harm, Yakhmi, J. V., Bagkar, Nitin, Scholz, Fritz

Journal:

Inorganic Chemistry

Year:

2002

Language:

english

File:

PDF, 269 KB

english, 2002

30

The role of potassium channel Kv1.3 in Aß-induced microglia activation

Izumi Maezawa, Paul David Jenkins, Jessica Sexton, Heike Wulff, Lee-Way Jin

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 57 KB

english, 2012

31

Ca++T LAB - A Computational Model for Intracellular Calcium Signaling In T Lymphocytes

Lal, Rayhan, Puglisi, Jose L., Wulff, Heike, Bers, Donald M.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 36 KB

english, 2009

32

Mapping the Binding Site of the Alkoxypsoralen PAP-1 in the Voltage-Gated K+ Channel Kv1.3

Zimin, Pavel I., Garic, Bojan, Wulff, Heike, Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 42 KB

english, 2009

33

Potassium Channel Block by a Tripartite Complex of Neutral Ligands with a Potassium Ion

Zimin, Pavel I., Garic, Bojan, Wulff, Heike, Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

34

New Classes of Gap Junction Channel Blockers for Cx43 and Cx50

Bodendiek, Silke B., Rubinos, Clio, Srinivas, Miduturu, Wulff, Heike

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 44 KB

english, 2010

35

NS8593-Mediated Negative Gating Modulation Depends on Residues in the Inner Pore Vestibule of Kca2 Channels

Jenkins, David P., Hougaard, Charlotte, Jensen, Marianne L., Hummel, Rene, Sørensen, Ulrik, Wulff, Heike, Christophersen, Palle, Strøbæk, Dorte

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 39 KB

english, 2010

36

Kca3.1 Blockers as Potential New Drugs for the Prevention of Renal Fibrosis and Chronic Allograft Rejection

Wulff, Heike, Chen, Yi-Je, Schrepfer, Sonja, Köhler, Ralf

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 45 KB

english, 2010

37

Does microglial dysfunction play a role in autism and Rett syndrome?

Maezawa, Izumi, Calafiore, Marco, Wulff, Heike, Jin, Lee-Way

Journal:

Neuron Glia Biology

Year:

2011

Language:

english

File:

PDF, 574 KB

english, 2011

38

A New Class of Blockers of the Voltage-Gated Potassium Channel Kv1.3 via Modification of the 4- or 7-Position of Khellinone

Harvey, Andrew J., Baell, Jonathan B., Toovey, Nathan, Homerick, Daniel, Wulff, Heike

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 155 KB

english, 2006

39

Therapeutic potential of K Ca 3.1 blockers: recent advances and promising trends

Wulff, Heike, Castle, Neil A

Journal:

Expert Review of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 6.73 MB

english, 2010

40

The Structure Investigation of Copper, Nickel and Iron Hexacyanometalates from Conventional X-Ray Powder Diffraction Data

Petrovic-Prelevic, Irena, Widmann, Antje, Kahlert, Heike, Wulff, Harm, Scholz, Fritz

Journal:

Materials Science Forum

Year:

2004

Language:

english

File:

PDF, 725 KB

english, 2004

41

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

Lam, Jenny, Coleman, Nichole, Garing, April Lourdes A, Wulff, Heike

Journal:

Expert Opinion on Therapeutic Targets

Year:

2013

Language:

english

File:

PDF, 951 KB

english, 2013

42

Channels: Sticking to nooks and crannies

Wulff, Heike, Yarov-Yarovoy, Vladimir

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 570 KB

english, 2013

43

K + Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases

Wulff, Heike, Zhorov, Boris S.

Journal:

Chemical Reviews

Year:

2008

Language:

english

File:

PDF, 1.74 MB

english, 2008

44

SKA-31, A New Activator of KCa2 And KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure

Wulff, Heike, Sankaranarayanan, Ananthakrishnan, Raman, Girija, Busch, Christoph, Schultz, Tim, Zimin, Pavel I., Hoyer, Joachim, Köhler, Ralf

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 68 KB

english, 2009

45

A "FOYER" OF CHOLERA.

Wulff, Heike, Sankaranarayanan, Ananthakrishnan, Raman, Girija, Busch, Christoph, Schultz, Tim, Zimin, Pavel I., Hoyer, Joachim, Köhler, Ralf

Journal:

Year:

1893

Language:

english

File:

PDF, 179 KB

english, 1893

46

Microglial Kv1.3 Channels as a Potential Target for Alzheimer's Disease

Jenkins, David P., Maezawa, Izumi, Wulff, Heike, Jin, Lee-Way

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 39 KB

english, 2012

47

Development of a Qpatch Automated Electrophysiology Assay for Identifying Kca3.1 Inhibitors and Activators

Brown, Brandon M., Jenkins, David P., Yu, Weifeng, Løjkner, Lars D., Wulff, Heike

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 61 KB

english, 2014

48

Pharmacological Evidence For Deep Pore Gating In SK Channels

Strobaek, Dorte, Jensen, Marianne L., Hougaard, Charlotte, Sørensen, Ulrik S., Brown, David T., Jenkins, David P., Wulff, Heike, Christophersen, Palle

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 48 KB

english, 2009

49

SKA-111, a Positive KCa Channel Gating Modulator with Selectivity for KCa3.1

Coleman, Nichole T., Brown, Brandon M., Viguera, Aida O., Köhler, Ralf, Wulff, Heike

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 44 KB

english, 2014

50

Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcayji-hes mice

Luna-Cancalon, Katiuska, Sikora, Kristine M., Pappas, Samuel S., Singh, Vikrant, Wulff, Heike, Paulson, Henry L., Burmeister, Margit, Shakkottai, Vikram G.

Journal:

Neurobiology of Disease

Year:

2014

Language:

english

File:

PDF, 1.41 MB

english, 2014